Tuesday, June 11, 2019
Operating system assignment Example | Topics and Well Written Essays - 1500 words - 1
Operating system - Assignment Exampleis a procedure that a computers Central Processing Unit (CPU) follows to mixture from one task/process to another while ensuring that the tasks do not conflict. For a computer to provide user-friendly multi-tasking, it needs an effective context switching. In a computers CPU, the term context is used to refer to the particular program counter and registers at a specific moment in time. A CPUs current instruction is held by a register. The program counter Is also referred to as an instruction address register. It is a itsy-bitsy amount of quick memory that is used to hold the address of the instruction to be executed immediately after the current one. It is possible to suffice a context switch entirely in physical media, which is by use of hardw be. This is especially so in older CPUs, for example the x86 series. In the modern world, the CPUs perform context switches by means of programming/software. The modern CPUs are very fast and they are a ble to perform numerous context switches within seconds. This gives the user an impression of the performance of multiple tasks by the computer.Deadlock prevention is the process of averting deadlocks by restraining how demands for resources can be made in the system and how they are handled, that is system design. Its main objective is to ascertain that at any moment one of the significant conditions for deadlock can certainly not hold. Deadlock avoidance, on the other hand, is where the system vigorously contemplates every request and decides whether it is safe to grant it at that point. The system requires additional apriori information regarding the overall potential use of distributively resource for each process. Deadlock avoidance allows more concurrence than deadlock prevention.The benefit of a multithreaded programming that is presented by multicore systems is that programmers are able to complete more total operations than with one core alone. This is the concept of mult itasking. Instructions in a series are also able
Monday, June 10, 2019
Restaurant Ethnography Essay Example | Topics and Well Written Essays - 500 words
Restaurant Ethnography - Essay ExampleI decided to observe the behavior of the employees (waitresses, cashiers, chefs among others) in that locationby focusing on the importance of good behavior and customer relation in creating customer loyalty.Context Cottage Inn is a medium restaurant that serves the daily solid food needs of the habitats of Chesters Mill. It is find at the heart of the town, directly opposite Walmart Mall and besides Shell gas station. The restaurant serves various types of foods such as snacks, entrees and beverages, which are drafted in a stylish menu. Upon entry, there is a buffet service on the first right turn. I observed waiters standing so-and-so big silver dishes awaiting to serve the customers. On the left, is a classy burrito bar which contains all the necessary items that are needed to make a sandwich or a Mexican burrito.Opposite the burrito bar is a brand new machine which is used to produce blended juice. Besides, this restaurant has also adequat e aloofness that allows the customers to relax and have a clear view of the outside while dinning. The dining room, a huge room decorated with golden curtains and expensive furniture, is located on the first floor of the building. Leather couches are arranged all-round the dining room with large television sets positioned exactly opposite each couch, I carried out my observations seated on the middle couch since I could observe almost everything from that point.This observations spanned over a period half an hour. First, I noted that there were different jobs assigned to different employees who were expected to carry them out. There were a couple of workers including five chefs on the main kitchen, six cleaners ( deuce-ace downstairs and three upstairs), two ushers, one burrito bar attendant, one milk and beverage server and four to five dish washers. These workers were all cladded uniformly. They wore white head wears, black knee breeches and a white apron. They all looked neat a part from one whose shirt had been spilt over by soup.
Sunday, June 9, 2019
Business Policy and Strategy essay question Assignment
Business Policy and Strategy essay question - Assignment ExampleAnswer Byte executives should tell all future day stakeholders that the ingraft would run for a three years period only. The purpose behind such a straight and truthful approach is to create a aroma of loyalty among the community members that the company has a clean slate and is not trying to hide truth. It should be left on the prospective employees to adjust their bank line routine for the next three years only in Plainville. If not all, many would appreciate the companys truthfulness and transparency in bring out its intentions. This may also offer enough time to the prospective employees to plan their career accordingly and use their work experience in Plainville plant of Byte for their future growth, making them available for job offers by competitive companies thereafter.Answer Although Plainville is a small townspeople but it is an industrial town as well where jobs should be in plenty. Prospective candidates for taking jobs at Byte would be only those who value working in the leading company, producing electronic parts, used in personal computers. later on spending three years at Byte Products, Inc. Future job opportunities would be relatively lucrative. As there is no legal hurdle in offset a temporary plant at Plainville, corporate responsibility can be fulfilled by offering bonuses to all the employees or giving them more or less percentage of the profits earned for the mart risks covered from competitors, not succeeding in taking away orders of Byte. Future is always full of opportunities and possibilities. An industrial town like Plainville would take care of the supply side of the employment possibilities. When nothing is kept hidden, scope of anguish remains low. After all, it is private sector and the market is becoming increasingly competitive.Answer. In my opinion, the present impasse is based on the future negative outcomes. Assumptions of Williams that for staff strength of 1,200, at least 4,000 people allow need to shift after
Saturday, June 8, 2019
Bigamy & Alimony Essay Example for Free
Bigamy Alimony EssayIf fact of first marriage was concealed from the partner term of imprisonment may extend to 10 years In Sarla Mudgal v UOI AIR 1995 SC 1531, the SC criticized the practice of conversion to Islam for the sake of under weigh II bigamous marriage coz that enables them to marry again without getting their first marriage dissolved.The ruling was reaffirmed in the case of Lily Thomas v UOI AIR 2000 SC 1650. Also held plurality of marriage is not unconditional serious conferred on the Muslim husband. There is a precondition that he should have the capacity to do justice between the co-wives. under Hanafi Law 5 marriages are not void but merely irregular and can be regularized by divorcing iodine wife. Exception a Sunni taking a fifth wife is not guilty of Bigamy u/s 494, 495 of IPC ( Shahumeedu v Subajda ( 1970)But a Shia Husband who takes 5th marriage (where 5th marriage is void) can be prosecuted for bigamy. So, one who marries during the lifetime of his or her spouse commits an offence of bigamy provided his first marriage is not zip fastener void. In M. M. Malhotra v UOI AIR 2006 SC 80, Husband married a woman whose marriage was in subsistence but was void.Hence, held subsequent marriage would not be bigamous. If designer marriage is voidable, then also bigamy is committed. Varadrajan v State of Madras AIR 1965 SC 1964, Bigamy where requisite formalities of marriage have been performed at the time of the solemnization of II marriage. Priya v Suresh AIR 1971 SC 1153, held second marriage cannot be treated to be proved by mere admission of parties.Performance of appropriate ceremonies is to be proved. Dr. D.N. Mukherji v State AIR 1969 All. 486, held performance of some mock ceremony is not enough and, therefore, prosecution of bigamy will fail. So bigamous marriage is void under H, Christian and Parsi laws. Under SMA declaration of nullity of marriage can be obtained by either party.The spouse of 1stmarriage has no right to f ile a petition for nullity. Remedy is to file a declaratory suit to that effect u/s 34 of the Special Relief Act, 1963. Under Matrimonial law the spouse of 1st marriage may sue for dissolution on the ground that other party is living in adultery u/s 13 (1) (i) of HMA. Law Commission of IndiaIn 227th report, given on 5th Aug.2009, recommended in HMA after S. 17 ( punishment) S. 17 A be inserted that a married person, who is governed by this Act cannot marry again even after changing religion, unless- i. 1st one is dissolved orii. Declared null and voidIn accordance with law.And if such a marriage is contracted it will be null void and Shall attract application of S. 494,495 of IPC.no abnegation can be taken in the charge of bigamy that it was a i. in good faith orii. mistake of law.Only aggrieved party can electric chargeBut once case is filed State prosecutes the bigamous spouse. Should bigamy be permitted in some limited cases?In Goa, Daman Diu during Portuguese rule Hindu Husband was permitted to take II wife during the lifetime of 1st one but i. in specified casesii. With the consent of wifeKane (in History of Dharmashstra) suggested it should be tolerated for some classes on scotch grounds. Derrett also supports (Critique of Modern Hindu Law)Some arguments hold good for polyandry also, but present writers do not support this view.iii.
Friday, June 7, 2019
Us Womens History Essay Example for Free
Us Womens History EssayThe native Australian American women were trained to work hard in the fields and in the house. They were held responsible for over 75% of food production and the gathering of the fruits in the community. These women were responsible for making clothes for themselves and their families from the skin of rabbit and dear. The Native American women were allowed to dress in long dresses and leggings. The Native American women mostly practice agriculture when civilization of Europeans arrived and because of all their lives depends agriculture their economy grows with their own hard work spiritual role. As the women atomic number 18 the horse sense of the community, they are presumptuousness right to own land and in this they use for farming and inherit it to their descendants. In America native communities in 1600 century, women are given to have much power than European women, this is because Native American women are very hard working and they also have good feelings and near to their husbands, thusly they are given equal opportunity to rest of the community. Status of Women in the Southern and Northern coloniesIn the grey colonies women were legally subordinate to men, politically and thus far improved economically in the colonial period. Southern colonies the women were view less than the men, where they took advantage for their right in the society of inheriting the land of their late husbands. The southern colonies focus was on profit while northern colonies focus on religion. The northern colonies are better in status than southern colonies because northern women are married earlier, they had larger families and they live longer than their cousins on the other side of the ocean.Living conditions in the early Northern and southern colonies Living condition in early 1600 in north and south, colonies use Americans as slaves and servants for their plantations, but in late 1600 the African slaves became the primary source of America n slaves. Southern plantation used to give huge profit to the northern merchants. Colonies came to America for religion and looking for job as most of them escape war.Although they got a lot of resources, but they started colonizing Americans financial backing condition of Americans was too poor and white colonizes took these advantage and started employing some of the Americans and some of Americans bought as servant with 25- 50 dollars. The servants were given a small grubstake and if she or he was lucky, a few acres of land. Thus, some of the servants were treated fairly. Servants or slaves who are living at southern were treated as slaves without any payment. (Kramarde, Cheris. and Spender, Dale. 107) sprain citedKramarde, Cheris and Spender, Dale. Routledge International Encyclopedia of women. Routledge. (2000).
Thursday, June 6, 2019
Case Analysis Essay Example for Free
Case Analysis EssayStrategic Human Resource Man eonment unit of measurement 1 What is Strategic Management, and why is it critical to the success of an giving medication in meeting its goals and mission? Strategic management is setting priorities and goals within a business. Its use upd with upper management to tone a company and prepare for future out haves. Making a product that is highly profitable and easy for customers to use and benefit from is the main focus of orchard apple tree, Inc. The validation of apple, Inc. started in the 1970s and has been very profitable since. In 1978 they sold the Apple II and made billions of dollars from the product in less than three years. Between 1983 and 1984 Apple, Inc. lost sales and have fell into a crisis because of the slow processor speed and the compatible software. During this time it was hard for the organization due to competition. The problem Apple Inc. was facing at this time is different companies have found easier and faster ways for people to use the different products other than Apple, Inc. , during the 1985-1993 Apple, Inc. writheed global, thus making sales up to 1 billion and was the most profitable PC Company in the world.Being able to turn any company global in an organization is very profitable, most people like new products. The beginning of 1993-1997 Apple Inc. starting playing a role in K-12 grade helping out the school systems with education with the product and this helped them out tremendously. By 2008 Apple Inc. started charging premium charges on their product lettered that with their name would be sold all over the nation. They also came out with the iPod roughly selling over 150 of them. This was giving the customer portable melody and other exiting things and they still sell to this day.Today Apple, Inc. is one of the top rated organizations for iPhones, iPods, iPads, computer systems and much more. The only problem with Apple, Inc. now in this day in age is the competition . There are a lot more companies that are coming out with the same product just a different name. For example, the flame onset is the same thing as the iPad, just a different name brand. A lot of people are purchasing the competitors product instead of the Apple name brand product. The reason behind this is that people would rather pay $200. 00 dollars for a arouse Fire verses $500. 0 for the Apple iPad. Apple, Inc. needs to lower prices for their products so more and more people with purchase them. In years to come this is a critical problem that Apple, Inc. faces, to be successful in any organization you have to think like the customers. Majority of the customers are going to try and same money and buy the generic brand verses the name brand product. What Apple needs to do is, if they start seeing a drop in profit they would need to start lowering prices down to match their main competitors so that more people will purchase their product.One of the main problems in 2013 is Appl e iPad verses Amazon Kindle Fire. The Amazon Kindle Fire has been called a say-so iPad-killer by the media states (Nations, D). The Amazon Kindle Fire is $199 and can do everything the Apple iPad and do. They are very similar and its making the customer purchase the Kindle Fire instead. When looking at both products Instead of looking at the Kindle Fire verses the iPad in a direct match up of features, which would be about like comparing a Ford Escort to a Mercedes, (Nations, D).This is a great example of not only just the Amazon Kindle Fire verses Apple iPad, its everyday life. From the groceries that customers buy at the store to clothing lines at a local mall. Everything has a generic name and lower price and most of the top name brands are sold and get good profit simply a lot of people are trying to unless money for more important things like their childrens college or a vacation for the family, or just trying to get by with bills.So this would be a good example of why the K indle Fire is macrocosm called the iPad-killer, because more likely people will purchase the Kindle for the lower price. almost of the advantages of the Kindle Fire is the low cost and being able to use the amazon app store to purchase games, books, movies and much more. Some advantages of the iPad is its faster, has more stock and dual face cameras on the iPad 2. Both of the products use full-color back-lit displays so both of them will have problems in direct sunlight. Both of them are good but the main concern is the price.To stay successful you have to look at your main competitors products and come out with bigger and better things to catch the customers eye. With doing this the product needs to be reasonably priced and affordable to the public. Otherwise the customers will go for the cheaper one to save costs. A good example of this is looking deeper into strategic management and why it is important. Strategic management is all about change, and facing challenging situation s in the diddle place. Being able to except the change and work through it, and make important finiss and implement appropriate strategies.Some other examples of strategic management are resource limitations, changing environment, matching competitors, and improved decision making. Resource limitations is being able to deal with limited resources of money. A lot of business go through this and Apple Inc. went through it back in 1983-1984 Apple, Inc. was in a crisis and had to make important changes to make more profit. Matching competitors is very important, a business could go down in profit if other companies come out with a similar product.Improved decision making is very important due to change in a product or being able to come out with a new product. Strategic management is setting priorities and goals within a business. Its used with upper management to strengthen a company and prepare for future outcomes. References Nations, Daniel, ed. The Amazon Kindle Fire vs the Apple iPad. N. p. , n. d. Web. 5 May 2013. lthttp//ipad. about. com/od/Tablet_Computers_eReaders/a/The-Amazon-Kindle-Fire-Vs-The-Apple-Ipad. htm Sind, M. , amp Yoffie, D. B. (February, 2008) Apple, Inc. (Case Study) Retrieved from Harvard Business Online website
Wednesday, June 5, 2019
Functional Groups of Lisinopril
Functional Groups of LisinoprilThe IR spectra of pure showed vizors at which are consistent with the presence of the functional groups of lisinopril (Fig.no.12) Furthermore, the calibration curve of lisinopril obeyed Beers justness in the range of 10-60 g/ml (Fig.no.11)An IR spectrum of the medicate-polymer (methylcellulose) mixture was taken to study and check the medicine- polymer interaction. The spectrum revealed that not much interaction amongst the medicine and polymer (Fig.no.13).In TLC studies, the prepared lisinopril microspheres (M4, M7) showed (Table.no.9) the same Rf (0.5512, 0.5769) pass judgment as pure compound (0.5897) and no additional musca volitans were detected. TLC studies (Fig.no15) thus indicated no interaction mingled with lisinopril and polymer (methylcellulose) in the natation microspheres prepared. This observation also indicated that lisinopril was not decomposing during the preparation of drift microspheres. derivative instrument Scanning Colo rimetryThe thermal behavior of vagabond microspheres of lisinopril was studying using DSC are shown in (Fig no.16). The DSC thermogram of pure drug lisinopril exhibited an exothermic peak at corresponding to its thaw point. For formulation (M7) this peaks are at respectively. The characteristic exothermic peak is slightly shifted to lower temperature, indicating that there is no interaction amidst drug and carrier.Percentage passPercentage behave of polar batches of the prepared floating microspheres were determined by weighing the floating microspheres after drying. whole batches of methylcellulose floating microspheres showed a section yield of greater than 75%, the percentage yields of all the prepared formulations (M1-M9) were in the range of 76.8 to 92.16% (Table.no.11). Percentage yield is raise to be uplifted with formulation M7 (92.16%).Scanning negatron MicroscopyThe surface morphology of the prepared floating microsphere (M7) was shown to be spherical by the S EM photography (Fig.no.19).Particle size analysisThe portion size analysis was carried off using an optical microscope. The arithmetic mean particle size of the methylcellulose floating microspheres significantly increased with increasing polymer concentration were shown in (Table.no.18).The particle size dispersion of the methylcellulose floating microspheres ranged between 163.125 to 252.375m.Micromeritic properties of the floating microspheres 61The various micromeritic properties of the prepared floating microspheres were studied.Acceptable range of angle of calm is between 20-40 and angle of calmness for methylcellulose floating microspheres (M1-M9) was between 24.44 to 35.53 (Table no. ), thus indicating good flow property for methylcellulose floating microspheres.Acceptable range of Hausners ratio is up to 1.25 and Hausners ratio for methylcellulose floating microspheres(M1-M9) was between 1.085 to 1.181(Table.no.21) ,all the prepared floating microspheres had a value le ss than 1.25 thereby exhibiting good flow properties.Acceptable range of Carr,s index (%)is up to 5-21%, and carrs index for methylcellulose floating microspheres(M1-M9) was between 7.910 to 15.379 % (Table.no.21) all the formulations showed an Carr,s index (%) less than 16% and hence had a flow properties.Percentage drug content of the floating microspheresThe percentage drug content of different batches of floating microspheres was fix in the range of 55.33 to 88%.All batches of the methylcellulose floating microspheres formulation shown percentage drug content more than 55% (Table no.23) and it is found that percentage drug content increases with an increase in the polymer concentration (except M2,M6). Formulation M5 has shown maximum percentage drug content (88.0%).Buoyancy percentage (Floating ability)The buoyancy test was carried step forward to investigate the buoyancy percentage (floating ability) of the prepared methylcellulose floating microspheres. The buoyancy percent age of the different batches of floating microspheres was found in the range of 48.0 to 85.0% at the end of 12 hrs (Table.no.25). All the formulated floating microspheres of lisinopril showed buoyancy (floating ability) more than 48%. Amongst the batches of prepared methylcellulose floating microspheres, batch M5 showed highest buoyancy (85%). Floating ability of different formulations was found to be differed according to the increase polymer concentration and it is found that percentage of buoyancy increases with an increase in the amount of polymer.In-vitro pouch studiesLisinopril release from the all formulated floating microspheres were studied in SGF (0.1N HCl) for 12 hrs.The floating microspheres showed sustained release of the lisinopril (drug) in acidic environment and the drug release was found to be rough linear (fig no. ). The drug release from methylcellulose floating microspheres was found to be 82.35, 78.75, 74.25, 71.55, 66.15, 83.70, 90.45, 94.5 and 97.65% at the end of 12 h for M1,M2,M3,M4,M5,M6,M7,M8 and M9 respectively (Table.no.27). The sustained release linguistic rule was observe for the prepared floating microspheres (M1-M9) clearly exhibiting an increase in the polymer concentration results decrease in-vitro drug release of lisinopril. Amongst the batches of prepared methylcellulose floating microspheres, batch M5 showed higher drug entrapment power 88.0% and the minimal in-vitro drug release 66.15% at the end of the 12 hrs with compared to the other prepared methylcellulose floating microspheres.Drug release energisingsThe results for the mathematic modeling of the in-vitro drug release data for the methylcellulose floating microspheres have been complied and the R2 values shown in the table no.The in-vitro drug release profile for the formulations M1-M9 were subjected to various drug release kinetic studies and are depicted in the following figures. (Fig.no.30-38)The release profile for the formulations M1-M9 exhibiting a maximu m R2 values (0.9613, 0.9421, 0.9386, 0.9446, 0.9382, 0.9546, 0.9520, 0.9599 and 0.9660) was found to obey that particular kinetics. From the results it is apparent that the regression coefficient value close to unity as in the case of the Zero orders plots. The Zero order plots of different formulation were found to be fairly linear, as indicated by their high regression values. Thus, it seems that drug release from the floating microspheres followed Zero order kinetics. The data indicates a lesser amount of linearity when plotted by the frontmost order equation. Hence it can be concluded that the major mechanism of drug release follows Zero order kinetics.Further, the conversion of the data from the dissolution studies suggested misadventure of understanding the mechanism of drug release by configuring the data into various mathematical modeling such as Higuchis and Korsemeyers -peppas plots. The mass transfer with respect to forthright root of time has been plotted, revealed a linear graph with regression value close to one stating that the release from the matrix was through diffusion. Data based on the Higuchi model usually provide a evidence to the diffusion mechanism of drug release from matrix systems such as the methylcellulose floating microspheres developed in this work. R2 values based on the Higuchis model ranged from 0.8882, 0.8578, 0.8507, 0.8603, 0.8542, 0.8773, 0.8708, 0.8858 and 0.8978. (Table.no.29). As these values were close to 1.0, the drug release mechanism of the developed floating microspheres can be utter to be Higuchian and, therefore, matrix diffusion-controlled.CHITOSAN FLOATING MICROSPHERESIR Spectra of chitosan floating microspheresAn IR spectrum of the drug-polymer (chitosan) mixture was taken to study and check the drug- polymer interaction. The spectrum revealed that not much interaction between the drug and polymer (Fig.no.14).Thin Layer ChromatographyIn TLC studies, the prepared lisinopril microspheres (C4, C7) showed th e same Rf (0.5384, 0.5000) value as pure compound (0.5897) and no additional spots were detected(Fig.no.15). TLC studies thus indicated no interaction between lisinopril and polymer (chitosan) in the floating microspheres prepared. This observation also indicated that lisinopril was not decomposing during the preparation of floating microspheres.Differential Scanning ColorimetryThe thermal behavior of floating microspheres of lisinopril was studying using DSC are shown in Fig.no.17. The DSC thermogram of pure drug lisinopril exhibited an exothermic peak at corresponding to its melting point. For formulation (C7) this peaks are at respectively. The characteristic exothermic peak is slightly shifted to lower temperature, indicating that there is no interaction between drug and carrier.Percentage yieldPercentage yield of different batches of the prepared floating microspheres were determined by weighing the floating microspheres after drying. All batches of methylcellulose floating mic rospheres showed a percentage yield of greater than 75%, The percentage yields of all the prepared formulations (C1-C9) were in the range of 78.0 -93.66% (Table.no.12). Percentage yield is found to be higher with formulation C7 (93.66%).Scanning Electron MicroscopyThe surface morphology of the prepared floating microsphere (C7) was shown to be spherical by the SEM photography (Fig.no.20).Particle size analysisThe particle size analysis was carried out using an optical microscope. The arithmetic mean particle size of floating microspheres significantly increased with increasing polymer concentration were shown in Table. No. 19. The particle size distribution of the chitosan floating microspheres ranged between 32.50 to 55.80m.Micromeritic properties of the floating microspheres 61The various micromeritic properties of the prepared floating microspheres were studied.Acceptable range of angle of repose is between 20-40 and angle of repose for chitosan floating microspheres (C1-C9) was between 19.02 to 23.49 (Table.no.22), thus indicating good flow property for chitosan floating microspheres.Acceptable range of Hausners ratio is up to 1.25 and Hausners ratio for chitosan floating microspheres(C1-C9) was between 1.100 to 1.230 (Table.no.22) ,all the prepared floating microspheres had a value less than 1.25 thereby exhibiting good flow properties.Acceptable range of Carr,s index (%)is up to 5-21%, and carrs index for chitosan floating microspheres(C1-C9) was between 9.090 to 18.746% (Table.no.22) all the formulations showed an Carr,s index (%) less than 18% and hence had a flow properties.Percentage drug content of the floating microspheresThe percentage drug content of different batches of floating microspheres was found in the range of 50.66 to 88.0%.All batches of the chitosan floating microspheres formulation shown percentage drug content more than 50% (Table.no.24) and it is found that percentage drug content increases with an increase in the polymer concentrat ion. Formulation C5 shown maximum percentage drug content (88.0%).Buoyancy percentage (Floating ability)The buoyancy test was carried out to investigate the buoyancy percentage (floating ability) of the prepared chitosan floating microspheres. The buoyancy percentage of the different batches of floating microspheres was found in the range of 46.0 to 82.0% at the end of 12 hrs (Table.no.26). All the formulated floating microspheres of lisinopril showed buoyancy (floating ability) more than 46%. Amongst the batches of prepared chitosan floating microspheres, batch C5 showed highest buoyancy (85%). Floating ability of different formulations was found to be differed according to the increase polymer concentration and it is found that percentage of buoyancy increases with an increase in the amount of polymer.In-vitro release studiesLisinopril releases from the all formulated floating microspheres were studied in SGF (0.1N HCl) for 12 hrs.The floating microspheres showed sustained release of the lisinopril (drug) in acidic environment and the drug release was found to be just about linear (Fig.no.29). The drug release from chitosan floating microspheres was found to be 66.6, 61.65, 58.95, 57.15, 52.2, 69.3, 71.55, 74.7 and 78.75% at the end of 12 h for C1,C2,C3,C4,C5,C6,C7,C8 and C9 respectively (Table.no.28). The sustained release pattern was observed for the prepared floating microspheres (C1-C9) clearly exhibiting an increase in the polymer concentration results decrease in-vitro drug release of lisinopril. Amongst the batches of prepared chitosan floating microspheres, batch C5 showed higher drug entrapment efficiency 88.0% and the minimal in-vitro drug release 52.2% at the end of the 12 hrs with compared to the other prepared chitosan floating microspheres.Drug release kineticsThe results for the mathematic modeling of the in-vitro drug release data for the methylcellulose floating microspheres have been complied and the R2 values shown in the table no.The in- vitro drug release profile for the formulations C1-C9 were subjected to various drug release kinetic studies and are depicted in the following figures. (Fig.no.39-47)The release profile for the formulations C1-C9 exhibiting a maximum R2 values (0.9834, 0.9646, 0.9556, 0.9244, 0.9305, 0.9656, 0.9655, 0.9646, and 0.9759) were found to obey that particular kinetics. From the results it is apparent that the regression coefficient value closer to unity as in the case of the Zero orders plots. The Zero order plots of different formulation were found to be fairly linear, as indicated by their high regression values .Thus, it seems that drug release from the floating microspheres followed Zero order kinetics. The data indicates a lesser amount of linearity when plotted by the first of all order equation. Hence it can be concluded that the major mechanism of drug release follows Zero order kinetics.Further, the conversion of the data from the dissolution studies suggested fortuity of under standing the mechanism of drug release by configuring the data into various mathematical modeling such as Higuchis and Korsemeyers -peppas plots. The mass transfer with respect to consecutive root of time has been plotted, revealed a linear graph with regression value close to one stating that the release from the matrix was through diffusion. Data based on the Higuchi model usually provide a evidence to the diffusion mechanism of drug release from matrix systems such as the chitosan floating microspheres developed in this work. R2 values based on the Higuchis model ranged from 0.9238, 0.8905, 0.8751, 0.8295, 0.8392, 0.8955, 0.8993, 0.8986 and 0.9236. (Table.no.30). As these values were close to 1.0, the drug release mechanism of the developed floating microspheres can be verbalize to be Higuchian and, therefore, matrix diffusion-controlled.
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